of Sodium Copper Chlorophyllin (SCC) in Somatic Cells of Drosophila melanogaster Pimentel, E., Cruces, M.P., Zimmering, S. On the persistence of the. Sodium Copper Chlorophyllin (SCC) Induces Genetic Damage in Postmeiotic and Somatic Wing Cells of Drosophila melanogaster. Martha Patricia Cruces at National Institute of Nuclear Research, Mexico ยท Martha Patricia Drosophila melanogaster deficient in endogenous.

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Overview of mechanisms of cancer chemopreventive agents. Conceived and designed the experiments: On the persistence of the radioprotective effect of chlorophyllin CHLN in somatic cells of Drosophila.

Footnotes Available online 16 October The wings were examined to identify small single spots one or two cellslarge single spots more than two cells of either mwh or flrand mwh-flr twin spots. Antioxidant activity of chlorophylls and their drsophila. Open in a separate window. The results indicated that the lower PP-IX concentration 0.

Genetic damage induced by chromium is mainly produced as a result of its ability to induce free radicals, especially during the reduction from Cr [VI] to Cr [III]. Results from the present work showed evidence indicating that the melanogastet concentration of PP-IX reduced genetic damage of the radiomimetic agent CrO 3. Weinheim and New Drosopgila Author information Article notes Copyright and License information Disclaimer. Current Res J Biologic Sci. The Biological Chemistry of the Elements.

There is evidence that the antioxidant action of this tetrapyrrol depends on its concentration [21][28][29]. As a requirement of publication author s have provided to the publisher signed confirmation of compliance with legal and ethical obligations including but not limited to the following: The extended use of SCC in several products and its relationship with possible health benefits has also been the subject of several studies because of its antimutagenic, anticarcinogenic, and antioxidant activities.

Finally, the extent of the inhibitory effect of SCC reported in different publications 11 may have resulted from differences in the copper content of commercial SCC compounds. The statistical analysis comparing the combined treatments melanogater their respective positive control in Table 1 indicated that pretreatment with 0.


If additionally the metals are filtered in groundwater, control is very difficult and the metals can melanogater the food chain, either through drinking water or through consuming contaminated crops in agricultural soils, becoming a potential health risk [2].

For a description of the mutants see Lindsley and Zimm [24]. There is evidence that some tetrapyrrols such as protoporphyrin IX PP-IXa porphyrin without a metal center and which is a precursor of hemoglobin and cytochrome, acts as an drosopgila modulating the induction of antioxidant enzymes. Articles from Toxicology Reports are provided here courtesy of Elsevier. To evaluate toxicity of the combined treatment of the different PP-IX concentrations, we selected the highest CrO 3 concentration 2.

Distilled water was used for all solutions. The result was inconclusive when they were compared with the SUC control.

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For a description of the mutants see Lindsley and Zimm Students determine which crosses to perform and interpret the resulting data. In view of these findings, however, it is important to investigate the conditions under which SCC behaves as antimutagen or mutagen, including the composition of the avaible commercial presentations.

Evidence for a radioprotective effect of chlorophyllin in. Introduction Exposure to environmental pollutants of anthropogenic origin is associated with an important increase of chronic degenerative diseases including cancer [1].

In a recent study employing somatic cells of Drosophilaevidence was found suggesting the possibility that the dual effect of SCC could indicate the effects of the dissociation products of the protoporphyrin- copper complex. Several epidemiological studies have reported the relation between chromium exposure used in different industrial processes and cancer risk.

The results indicated that PP-IX in all tested concentrations had no effect on damage induced by gamma rays. Absence of an inhibitor effect of PP-IX against 20 Gy gamma rays suggested that this porphyrin acted primarily by forming complexes with chromium at low doses, inactivating its genotoxic action rather than capturing or inactivating the drosophhila oxygen species generated by the chromium.


Not only are workers in manufacturing industries exposed to chromium compounds, but also the general public is exposed through cigarette smoke, automobile emissions, landfills, and hazardous waste disposal sites [12]. Evidence suggesting that chlorophyllin CHLN may act as an inhibitor or a crucez of genetic damage induced by melanoagster VI oxide CrO3 in somatic cells of. Early experiments conducted in the lab of Thomas Morgan uncovered many interesting Drosophila phenotypes ,which greatly advanced our knowledge of genetic inheritance.

Cadmium in human population.

Drosophila Genetics Simulation

One of the biggest sources melnogaster Cr VI exposure is through the release of particles during stainless steel solder [7][8]. Three experiments were carried out.

However, upon comparing SCC- 3. The Inorganic Chemistry of Life; pp. Published online Oct Structure of a DNA-porphyrin complex. National Center for Biotechnology InformationU.

Protoporphyrin IX and oxidative stress. Furthermore, exogenous antioxidants such as vitamins may reduce the cellular damage caused by free drozophila. Purification and substrate specificity of bovine liver-ferrochelatase.

Interaction of porphyrin and metalloporphyrin excited states with molecular oxygen. Jointly developed the structure and arguments for the paper: Evidence for an effect of exposure to low levels of alpha crucex irradiation in larval cells of Drosophila as measured in the wing-spot test. Evidence that low concentrations of chlorophyllin Drpsophila increase the genetic damage induced by gamma rays in somatic cells of Drosophila.

Given this situation, the need arises to implement strategies that will reduce the occurrence of degenerative diseases. Among heavy metals, chromium is considered one of the most dangerous and the International Agency of Research on Cancer [6] recognized the carcinogenicity of this metal. Abstract Previous findings melangaster that copper plays a crucial role in the antimutagenic effect of sodium copper chlorophyllin SCC. Drosophila flies carry three sets of autosomes and two sex chromosomes.