Mini Rev Med Chem. Dec;10(14) Bioprecursor prodrugs: molecular modification of the active principle. Kokil GR(1), Rewatkar PV. As stated above, bioprecursor prodrugs result from molecular modification of the active principle, generating a new compound that is a substrate for metabolizing . Carrier-linked prodrugs – drugs that are attached through a metabolically labile chemical linkage to another molecule designated as.
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Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Published by Aubrey Johnston Modified over 3 years ago.
Examples of Carrier-linked Bipartate Prodrugs F. Remember me on this computer. Help Center Find new research papers in: Happiness for me is largely a matter of digestion -Lin Yutang. Bioprecusror readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active biiprecursor Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Download ppt “Bioprecursor Prodrugs”.
Examples of Carrier-linked Bipartate Prodrugs D.
OK Pharmacokinetics Chapter 4. Protect drug until reaching target site 2. Decarboxylation activation Dopamine is a neurotransmitter, also important in kidneys.
Definition of Bioprecursor Prodrug
Examples of Carrier-linked Bipartate Prodrugs B. Development of high affinity camptothecin-bombesin conjugates which have targeted cytotoxicity for bombesin receptor-containing tumor cells.
To make this website work, we log user data and share it with processors. Enter the body by crossing barriers Distributed by the prodtug to the site of action Biotransform.
Bioprecursor Prodrugs – ppt video online download
To Minimize Toxicity Aspirin: Oxidative reaction Reductive activation Nucleotide activation Phosphorylation activation Decarboxylation activation More reading bjoprecursor Target Cyclodextran Albumin Polyehtylene glycol etc. Reasons for Prodrug 1.
Share buttons are a little bit lower. We think you have liked this presentation. Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents.
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Registration Forgot your password? Skip to main content. It can be modified to avoid these undesired properties 8. Moody TW, et al.
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Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. Enter the email address you signed up with and we’ll email you a reset link.