REVISÃO. Atividade biológica e alcalóides indólicos do gênero Aspidosperma ( Apocynaceae): uma revisão. Biological activity and indole alkaloids of the genus . Este grupo incluye alrededor de 12, productos, entre los cuales se encuentran los alcaloides indólicos, alcaloides derivados del triptofano que conforman. Fly pollination in Ceropegia (Apocynaceae: Asclepiadoideae): biogeographic and phylogenetic perspectives. PubMed. Ollerton, Jeff; Masinde, Siro; Meve.

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Fly pollination in Ceropegia Apocynaceae: The taxonomic diversity of pollinators, biogeographic and phylogenetic patterns of pollinator exploitation, and the level of specificity of interactions were assessed in order to begin to understand the role of pollinators in alcaliodes diversification within the genus.

Flower visitor and pollinator data for approx. Size range of flies was 0.

Ceropegia from particular regions do not use specific fly genera or families, though Arabian Peninsula species are pollinated by a wider range of Diptera families than those in other regions. The basal-most clade interacts alcallides the highest diversity of Diptera families and genera, largely due to one hyper-generalist taxon, C.

Species in the more-derived clades interact with a smaller diversity of Diptera. The genus Ceropegia has largely radiated without evolutionary shifts in pollinator functional specialization, maintaining its interactions with small Diptera. Intriguing biogeographic and phylogenetic patterns may reflect processes of regional dispersal, diversification and subsequent specialization onto a narrower range of pollinators, though some of the findings may be caused by inconsistent sampling.

Comparisons are made with other plant genera. A concern about the declining supply of petroleum products has led to a renewed interest in evaluating plant species as potential alternate sources of energy. Five species of the Apocynaceae and three species of the Asclepiadaceae from the Western Ghats were evaluated as alternative sources of energ Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum, Apocynaceae.

Vincamine, a monoterpenoid indole alkaloid which had been marketed as nootropic drugs for the treatment of cerebral insufficiencies, is widely found in plants of the Apocynaceae family. Nerium indicum is a plant belonging to the Apocynaceae family. So, the purpose of this research was designed to investigate the vincamine alkaloids producing endophytic fungi from Nerium indicum, Apocynaceae. All fungal isolates were fermented and their extracts were preliminary screened by Dragendorff’s reagent and thin layer chromatography TLC.

One isolated strain CH1, isolated from the stems of Nerium indicum, had the same Rf value about 0. The extracts of strain CH1 were further analyzed by high performance liquid chromatography HPLC and liquid chromatograph-mass spectrometry LC-MSand the results showed that the strain CH1 could produce vincamine and vincamine analogues. The acetylcholinesterase AchE inhibitory activity assays using Ellman’s method revealed that the metabolites of strain CH1 had significant AchE alcaloies activity with an IC50 value of 5.

The isolate CH1 was identified as Geomyces sp. This study first reported the natural compounds tabersonine and ethyl-vincamine from endophytic fungi CH1, Geomyces sp. In conclusion, the fungal endophytes from Nerium indicum indoilcos be used as alternative source for the production of vincamine and vincamine analogues.

Horizontal transfer of DNA from the mitochondrial to the plastid genome and its subsequent evolution in milkweeds Apocynaceae. Horizontal gene transfer HGT of DNA from the plastid to the nuclear and mitochondrial genomes of higher plants is a common phenomenon; however, plastid genomes plastomes are highly conserved indlicos have generally been regarded as impervious to HGT.

We sequenced the kb plastome and the kb mitochondrial genome of common milkweed Asclepias syriaca [ Indokicos Essential oil composition of stems and fruits of Caralluma europaea N. The essential oil of the stems and fruits of Caralluma europaea Guss. Apocynaceae from Lampedusa Island has been obtained by hydrodistillation and its composition analyzed.

indllicos The analyses allowed the identification and quantification of 74 volatile compounds, of which 16 were aromatic and 58 non-aromatic. Stems and fruits contained 1. Non-aromatic hydrocarbons were the most abundant compounds in both organs, followed by fatty acids. Data showed differences in the profiles between stems and fruits which shared only eighteen compounds; stems accounted for 38 compounds while fruits for Indolicow showed a higher diversity especially in aromatic compounds with twelve versus four in stems.


Among the volatiles identified in stems and fruits of C. The possible ecological role of the volatiles found is briefly discussed. Bisindole natural products consist of two monomeric indole alkaloid indolocos as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.

In addition, the synthesis of bisindoles are far more challenging than the synthesis of monomeric indole alkaloids. Herein is reviewed the enantiospecific total and partial synthesis of bisindole alkaloids isolated primarily from the Alstonia genus of the Apocynaceae family.

The monomeric units belong to the sarpagine, ajmaline, macroline, vobasine, and pleiocarpamine series.

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An up-to-date discussion of their isolation, characterization, biological activity as well as approaches alcaloldes their partial and total synthesis by means of both synthetic and biosynthetic strategies are presented. A reassessment of Marquesan Ochrosia and Rauvolfia Apocynaceae with two new combinations. A reassessment of collections of Marquesan Apocynaceae assigned to the genera Alcaloieds Raf. As a result, two species each of Ochrosia and Rauvolfia are recognized from the Marquesas Islands, all endemic.

Recent field work has yielded important new data on their distribution, habitat, and conservation status. Abstract A reassessment of collections of Marquesan Apocynaceae assigned to the genera Neisosperma Raf. Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra.

The chemical investigation of the extract of the dried leaves of Rauvolfia caffra Sond synonym Rauvolfia macrophylla Apocynaceae led to isolation of a new glycoside derivative, rauvolfianine 1 as well as six known compounds: Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Their structures and relative stereochemistry were elucidated by spectroscopic methods.


Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species. The anticancer properties of Apocynaceae species are well known in barks and roots but less so in leaves. In this study, leaf extracts of 10 Apocynaceae species were assessed for antiproliferative APF activities using the sulforhodamine B assay. Leaf extracts of Alstonia angustiloba, Calotropis gigantea, Catharanthus roseus, Nerium oleander, Plumeria obtusa, and Vallaris glabra displayed positive APF activities.

Dichloromethane DCM extract of C. MeOH extracts of V. All four extracts of N. The wide-spectrum APF activities of these three species are reported for the first time and their bioactive compounds warrant further investigation.

Development and evolution of extreme synorganization in angiosperm flowers and diversity: Apocynaceae and Orchidaceae are two angiosperm families with extreme flower synorganization. They lacaloides unrelated, the former in eudicots, the latter in monocots, but they indokicos in the formation of pollinia and pollinaria, which do not occur in any other angiosperm indolicps, and for which extreme synorganization of floral organs is a precondition.

Alczloides each family extensive studies on flower development and evolution have been performed; however, newer comparative studies focusing on flower synorganization and involving both families together are lacking.

For this study an extensive search through the morphological literature has been conducted. Alcaloide on this and my own studies on flowers in various Apocynaceae and Orchidaceae and complex flowers in other angiosperms with scanning electron microscopy and with microtome section series, insolicos review on convergent indokicos traits in flower development and architecture in the two families is presented.

There is a tendency of protracted development of synorganized parts in Apocynaceae and Orchidaceae development of synorganization of two or more organs begins earlier the more accentuated it is at anthesis. Synorganization or indolicis also paves the way for novel structures. One alcalooides the most conspicuous such novel structures in Apocynaceae is the corona, which is not the product of synorganization of existing organs; however, it is probably enhanced by synorganization of other, existing, floral parts.


In contrast to synorganized parts, the corona appears developmentally late. Synorganization of floral organs may lead to a large number of convergences in clades that are only very distantly related. The convergences that have been highlighted in this comparative study should be developmentally investigated directly in parallel in future studies. For Permissions, please email: Background and Aims Apocynaceae and Orchidaceae are two angiosperm families with extreme flower synorganization.

Scope For this study an extensive search through the morphological literature has indolixos conducted. Key Findings There is a tendency of protracted development of synorganized parts in Apocynaceae and Orchidaceae development of synorganization of two or more organs begins earlier the more accentuated it is at anthesis. Conclusions Synorganization of floral organs may lead to a large number of convergences in clades that indoliocs only very distantly related.

The nuclear genome of Rhazya stricta and the evolution of alkaloid diversity in a medically relevant clade of Apocynaceae. Alkaloid accumulation in plants is activated in response to stress, is limited in distribution and specific alkaloid repertoires are variable across taxa.

Rauvolfioideae ApocynaceaeGentianales represents a major center of structural expansion in the monoterpenoid indole alkaloids MIAs yielding thousands of unique molecules including highly valuable chemotherapeutics.

The paucity of genome-level data for Apocynaceae precludes a deeper understanding of MIA pathway evolution hindering the elucidation of remaining pathway enzymes and the improvement of MIA availability in planta or in vitro. We sequenced the nuclear genome of Rhazya stricta ApocynaceaeRauvolfioideae and present inddolicos high quality assembly in comparison with that of coffee Rubiaceae, Coffea canephora, Gentianales and others to investigate indoolicos evolution of genome-scale features.

The annotated Rhazya genome was used to develop the community resource, RhaCyc, a metabolic pathway database. Gene family trees were constructed to identify homologs of MIA pathway genes and to examine their evolutionary history. We found that, unlike Coffea, the Rhazya lineage has experienced many structural rearrangements.

Gene tree analyses suggest recent, lineage-specific expansion and diversification among homologs encoding MIA pathway genes in Gentianales and provide candidate sequences with the potential to close gaps in characterized pathways and support prospecting for new MIA production avenues.

Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species. Background Studies have shown that the barks and roots of some Apocynaceae species have anticancer and antimalarial properties.

In this study, leaf extracts of five selected species of Apocynaceae used in traditional medicine Alstonia angustiloba, Calotropis gigantea, Dyera costulata, Kopsia fruticosa and Indolicoa glabra were assessed for antiproliferative APF and antiplasmodial APM activities, and analysed for total alkaloid content TACtotal phenolic content TPC and radical-scavenging activity RSA.

Screening for saponins, tannins, cardenolides and terpenoids were conducted alcaloires the frothing, ferric chloride, Kedde and vanillin-H2SO4 tests, respectively. Alcaloiddes Leaf extracts of A. DCM extract of A.

All five species were effective against K1 strain indoicos Plasmodium falciparum and three species C. Against K1 strain, all four extracts of V.

Selectivity index values of extracts of A. Antitumor effect of laticifer proteins of Himatanthus drasticus Mart. Plumel – Apocynaceae is a medicinal plant popularly known as Janaguba. Its bark and latex have been used by the public for cancer treatment, among other medicinal uses.

However, there is almost no scientific research report on its medicinal properties. The aim of this study was to investigate the antitumor effects of Himatanthus drasticus latex proteins HdLP in experimental models.